Semaglutide
Originally developed as a medication to treat Type-2 Diabetes, Semaglutide has been adopted as an effective tool to combat obesity in recent years. It is a glucagon-like peptide-1 (GLP-1) agonist, which mimics the GLP-1 hormone. GLP-1 is a hormone in the gut that is released in response to eating. In higher amounts, it interacts with the brain in a manner that suppresses appetite and causes a lasting feeling of fullness.
After 68 weeks, half of clinical trial participants lost 17% of their initial body weight, and another third lost 20% with improved diet and exercise. Many individuals regained weight after stopping the medication, which highlights the importance of long-term strategy.
Other Benefits
- Reduces risk of major cardiovascular events (death, heart attack, or stroke) in adults with heart disease
- Potent anti-inflammatory effects
- Helps reduce amyloid protein buildup in the brain (linked to Alzheimer’s)
- Shown potential in treating substance use disorders by reducing cravings
- Improves blood sugar regulation
- Lowers risk of COVID-19-related complications
- Fewer outbreaks of hidradenitis suppurativa
Side Effects
Of all GLP-1 medications, Semaglutide has one of the highest rates of side effects. These may include:
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Abdominal pain
- Headache
- Fatigue
- Dizziness
- Sulfur-smelling burps
- Gas and bloating
- Heartburn
- Runny nose
- Sore throat
Less Common but More Serious Side Effects
- Thyroid tumors and/or cancer
- Inflammation of the pancreas
- Gallbladder disease
- Gastroperesis (stomach paralysis)
- Kidney failure
- Changes in vision (esp. for diabetics)
- Depression or suicidal ideation
- Increased heart rate
- Hypoglycemia (especially if combined with insulin or sulfonylureas)
Contraindications
Do NOT take Semaglutide if:
- You are allergic or hypersensitive to any ingredients
- You are pregnant or breastfeeding
- You have thyroid disease
- You or your family has a history of medullary thyroid cancer
- You have Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2)
- You have gallbladder disease or pancreatitis
Consult your physician before use if you have:
- Hypoglycemia
- Chronic eye disease
- Severe gastrointestinal disorders
- Pancreatic or kidney problems
- Type-2 diabetes with diabetic retinopathy
- Upcoming surgery or procedures using anesthesia
Dosing Protocol (Semaglutide: 5 mg vial)
Mix 5 mg with 1 mL (100 units) of bacteriostatic water
Subcutaneous administration
Dose once weekly, on the same day each week
If prone to side effects, take the dose before bedtime
Dosing Schedule (5 mg vial)
- 5 units = 0.25 mg
- 10 units = 0.5 mg
- 15 units = 0.75 mg
- 20 units = 1 mg
- 25 units = 1.25 mg
- 30 units = 1.5 mg
- 35 units = 1.75 mg
- 40 units = 2 mg
- 45 units = 2.25 mg
- 50 units = 2.5 mg
Dosing Protocol (Semaglutide: 10 mg vial)
Mix 10 mg with 2 mL (200 units) of bacteriostatic water
Subcutaneous administration
Dose once weekly, on the same day each week
Remain on each dose for a minimum of 4 weeks before increasing
Dosing Schedule (10 mg vial)
- 5 units = 0.25 mg
- 10 units = 0.5 mg
- 15 units = 0.75 mg
- 20 units = 1 mg
- 25 units = 1.25 mg
- 30 units = 1.5 mg
- 35 units = 1.75 mg
- 40 units = 2 mg
- 45 units = 2.25 mg
- 50 units = 2.5 mg
Stacking Suggestions
- AOD-9604 – improves fat loss, supports body recomposition, and helps break plateaus during Semaglutide use
- L-Carnitine – enhances energy and fat oxidation, especially helpful for users experiencing fatigue
- NAD+ – supports mitochondrial repair and boosts metabolism and cellular energy
- BPC-157 / TB-500 – reduce gut inflammation, promote healing, and improve systemic resilience under calorie restriction
- CJC-1295 / Ipamorelin – preserves lean muscle and supports GH signaling, making weight loss safer and more sustainable
- Glutathione – supports liver function, detox pathways, and systemic inflammation reduction
For long-term use, consider rotating with Tirzepatide or Retatrutide under medical supervision to prevent desensitization.
